Boron tribromide → HCID 57471167、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[Cl:27])[CH2:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:16]C)[CH:14]=2)[CH2:9][CH2:8][CH:7]1[NH:18][C:19](=[O:23])[O:20][CH2:21][CH3:22].B(Br)(Br)Br>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][C:26]=1[Cl:27])[CH2:5][CH:6]1[C:15]2[C:10](=[CH:11][CH:12]=[C:13]([OH:16])[CH:14]=2)[CH2:9][CH2:8][CH:7]1[NH:18][C:19](=[O:23])[O:20][CH2:21][CH3:22]参加物
4
実験手順
Ethyl 1-(3,4-dichlorobenzyl)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylcarbamate (2.1 g, 5.14 mmol) was dissolved in CH2Cl2 (50 ml) and BBr3 (3.87 g, 15.4 mmol) was added at −10° C. The reaction mixture was slowly warmed to RT and stirred for 2 h. The reaction mixture was added to ice water and extracted with CH2Cl2. The organic layer was washed with NaHCO3 solution and NaCl solution, then dried on MgSO4 and the solvent was removed. The product was obtained as a brown oil (2.05 g, 5.14 mmol, 100%).