Hydrochloric Acid → HCID 57467210、化合物
反応式
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][CH:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH:18]([F:20])[F:19])[CH:15]=3)[CH2:10][CH2:9][CH:8]2[NH:21]C(=O)OC(C)(C)C)=[CH:4][CH:3]=1.Cl>ClCCl>[ClH:1].[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][CH:7]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:17][CH:18]([F:20])[F:19])[CH:15]=3)[CH2:10][CH2:9][CH:8]2[NH2:21])=[CH:4][CH:3]=1参加物
4
実験手順
tert-Butyl [1-(4-chlorobenzyl)-7-(difluoromethoxy)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate (30 mg, 0.069 mmol) was dissolved in dichloromethane (2 mL). 5N isopropanolic hydrochloric acid (0.3 mL) were added and the reaction mixture was stirred at room temperature for 3 h. The solvents were evaporated in vacuo. Yield: 26 mg (0.069 mmol, 100%, colorless solid).
後処理
- customThe solvents were evaporated in vacuo