1-Propanesulfonyl chloride → Propane-1-sulfonic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester

HRID 1044538ノート

反応式

HRID 1044538 の反応式
[CH:1]1([N:4]([CH2:11][CH2:12][OH:13])[S:5]([CH2:8][CH2:9][CH3:10])(=[O:7])=[O:6])[CH2:3][CH2:2]1.[CH2:14]([S:17](Cl)(=[O:19])=[O:18])[CH2:15][CH3:16]>C(Cl)Cl.CN(C1C=CN=CC=1)C>[CH:1]1([N:4]([S:5]([CH2:8][CH2:9][CH3:10])(=[O:7])=[O:6])[CH2:11][CH2:12][O:13][S:17]([CH2:14][CH2:15][CH3:16])(=[O:19])=[O:18])[CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 662791-Propanesulfonyl chlorideHCID 43577530Propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide

生成物 1

HCID 59547799Propane-1-sulfonic acid 2-[cyclopropyl-(propane-1-sulfonyl)-amino]ethyl ester収率 78.8%

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒3 回

実験手順

To a solution of propane-1-sulfonic acid cyclopropyl-(2-hydroxy-ethyl)-amide (150 mg, 0.8 mmol) in CH2Cl2 and DMAP (97 mg, 0.8 mmol) was added dropwise a solution of propane-1-sulfonyl chloride (97 mg, 0.8 mmol) in CH2Cl2. The resulting mixture was stirred at room temperature over night, diluted with 50 ml of CH2Cl2, extracted subsequently with water, 1 M HCl, and brine, tried over Na2SO4, filtered and the solvent evaporated to obtain 197.5 mg of product which was used in the next step without further purification.

後処理

  1. extractionextracted subsequently with water, 1 M HCl, and brine
  2. filtrationfiltered
  3. customthe solvent evaporated

出典と根拠

ORDレコード
ord-f5d8b55fc77d4f1394aa5850acffb7c5
出典データセット
uspto-grants-2013_10
特許番号
US08563617B2

反応ノート

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