Hydroxyacetonitrile → [Cyclopentyl(isopropyl)amino]acetonitrile

HRID 10449

反応式

HRID 10449 の反応式
O[CH2:2][C:3]#[N:4].[CH:5]([NH:8][CH:9]1[CH2:13][CH2:12][CH2:11][CH2:10]1)([CH3:7])[CH3:6]>O.C(O)C>[CH:9]1([N:8]([CH2:2][C:3]#[N:4])[CH:5]([CH3:7])[CH3:6])[CH2:13][CH2:12][CH2:11][CH2:10]1

参加物

5

反応物 2

HCID 7857HydroxyacetonitrileHCID 17750362N-Isopropylcyclopentanamine

生成物 1

HCID 21978305[Cyclopentyl(isopropyl)amino]acetonitrile

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Hydroxyacetonitrile (8.2 ml of a 70% w/w solution in water, 0.1 mol) was added to a solution of N-isopropylcyclopentanamine (11.43 g, 0.09 mol) (Preparation 23) in ethanol (60 ml). The reaction mixture was heated under reflux for 3 hours, allowed to cool and the solvent removed under reduced pressure. The residue was purified by chromatography on silica gel eluting with dichloromethane:methanol (98:2, by volume) to give the title compound (14.1 g) as a clear oil.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureunder reflux for 3 hours
  3. temperatureto cool
  4. customthe solvent removed under reduced pressure
  5. customThe residue was purified by chromatography on silica gel eluting with dichloromethane:methanol (98:2, by volume)

出典と根拠

ORDレコード
ord-2edc0f68f55d4d2e9a504b31994f60af
出典データセット
uspto-grants-2006_08
特許番号
US07094769B2

関連ノート

読み込み中…