Sodium Bisulfite → 7-Fluoro-2,3-dihydro-1h-indol-2-one

HRID 1045039ノート

反応式

HRID 1045039 の反応式
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH:7]2SC.S(=O)(O)[O-].[Na+]>O>[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2

参加物

4

反応物 2

HCID 23665763Sodium BisulfiteHCID 569635307-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 37343717-Fluoro-2,3-dihydro-1h-indol-2-one収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
25 °C

実験手順

7-Fluoro-3-(methylsulfanyl)-1,3-dihydro-2H-indol-2-one (270.5 g) was dissolved in water (2000 g) and admixed with sodium bisulfite (300 g). The mixture was heated to reflux, in the course of which it was vigorously stirred. After 2.25 h, the mixture was cooled to 25° C. and isolated by filtration on a suction filter. It was washed twice with water (500 g each time) and then dried under reduced pressure (<50 mbar, 50° C.). This gave 7-fluoro-1,3-dihydro-2H-indol-2-one as a white solid (206.3 g, 95.1% by weight, 95% yield).

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux, in the course of which it
  3. customisolated by filtration on a suction
  4. filtrationfilter
  5. washIt was washed twice with water (500 g each time)
  6. customdried under reduced pressure (<50 mbar, 50° C.)

出典と根拠

ORDレコード
ord-55c6420b1cdb4957ae254223264664a4
出典データセット
uspto-grants-2013_10
特許番号
US08563749B2

反応ノート

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