ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Acetic Acid → 2-(((3aR,4S,6R,6aS)-6-(7-Chloro-5-(propylthio)-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)oxy)ethanol

HRID 1045071
ノート
印刷プレビュー

反応式

HRID 1045071 の反応式
[NH2:1][C:2]1[C:3]([NH:13][C@H:14]2[C@@H:18]3[O:19][C:20]([CH3:23])([CH3:22])[O:21][C@@H:17]3[C@@H:16]([O:24][CH2:25][CH2:26][OH:27])[CH2:15]2)=[N:4][C:5]([S:9][CH2:10][CH2:11][CH3:12])=[N:6][C:7]=1[Cl:8].C(O)(=O)C.[N:32]([O-])=O.[Na+].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1.O>[Cl:8][C:7]1[C:2]2[N:1]=[N:32][N:13]([C@H:14]3[C@@H:18]4[O:19][C:20]([CH3:22])([CH3:23])[O:21][C@@H:17]4[C@@H:16]([O:24][CH2:25][CH2:26][OH:27])[CH2:15]3)[C:3]=2[N:4]=[C:5]([S:9][CH2:10][CH2:11][CH3:12])[N:6]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 176Acetic AcidHCID 11430Potassium CarbonateHCID 102021862-(((3aR,4S,6R,6aS)-6-((5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanolHCID 23668193Sodium Nitrite

生成物 1

HCID 210357742-(((3aR,4S,6R,6aS)-6-(7-Chloro-5-(propylthio)-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl)oxy)ethanol

試薬・触媒・溶媒 2

HCID 962Water溶媒3 回HCID 1140Toluene溶媒

実験手順

To 2-[((3 aR,4S,6R,6aS)-6-{[5-Amino-6-chloro-2-(propylthio)pyrimidin-4-yl]amino}-2,2-dimethyltetrahydro-3 aH-cyclopenta[d][1,3]dioxol-4-yl)oxy]ethanol (180 kg) in toluene (749 kg) and acetic acid (153 kg) were added sodium nitrite (33.2 kg) in water (88 kg) charged with a rate that kept the temperature of the reaction ≦30° C. After the conversion criterion was reached (>99%) potassium carbonate (176 kg) in water (360 kg) was added to the reaction solution whereafter the water layer was separated off and the organic-layer was used in the next step.

後処理

  1. additioncharged with a rate that
  2. customthe temperature of the reaction ≦30° C
  3. customwas separated off

出典と根拠

ORDレコード
ord-3a020897fa15454cb5a40a7a74a3b3c3
出典データセット
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08563755B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート