関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Methoxyacetohydrazide | HCID 2759532 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | Ethyl 6-cyanoimidazo[1,2-a]pyridine-3-carboxylate | HCID 67259960 | — |
| 溶媒 | Glycol monoethyl ether | HCID 8076 | — |
| 生成物 | HCID 178494722 | HCID 178494722 | — |
反応手順
To a solution of ethyl 6-cyanoimidazo[1,2-a]pyridine-3-carboxylate (24q) (265 mg, 1.23 mmol) and 2-methoxyacetohydrazide (193 mg, 1.85 mmol) in 2-ethoxyethanol (5 mL) was added NaOMe (0.5 M in MeOH, 3.7 mL). The mixture was heated at 110° C. in a sealed vial overnight. The reaction mixture was purified by HPLC to give 6-(3-(methoxymethyl)-1H-1,2,4-triazol-5-yl)imidazo[1,2-a]pyridine-3-carboxylic acid (99). MS m/z 274.1 (M+1)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08569283B2 |
|---|
| 出典データセット | uspto-grants-2013_10 |
|---|
| ORD ID | ord-8e382648660341ad8916191929ed4fac |
|---|
| 出典メモ | uspto-grants-2013_10 |
|---|
