Hydrochloric Acid → 2-Amino-1,2,3,4-tetrahydronaphthalen-1-one hydrochloride
反応式
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[NH:12]C(=O)C.[ClH:16]>>[ClH:16].[NH2:12][CH:3]1[CH2:4][CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]1=[O:1]参加物
3
反応条件
- 温度
- 100 °C
実験手順
N-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)-acetamide (16.5 g, 81 mmol) was added to 3N aqueous hydrochloric acid (270 ml) and stirred at 100° C. for 5 hours. After removal of the solvent, the precipitate was filtered, washed with ethanol, and dried to give 2-amino-3,4-dihydro-2H-naphthalen-1-one hydrochloride (16.0 g, 81 mmol, 100%) as white crystals.
後処理
- customAfter removal of the solvent
- filtrationthe precipitate was filtered
- washwashed with ethanol
- customdried
出典と根拠
- ORDレコード
- ord-fb5cffc5d4ed44b6b6e3b9215c0b67fa
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569294B2
反応ノート
読み込み中…