Hydrochloric Acid → 3-Phenylpyrrolidine
反応式
Cl.C(OC([N:9]1[CH2:13][CH2:12][CH:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10]1)=O)(C)(C)C>C(OCC)(=O)C>[C:14]1([CH:11]2[CH2:12][CH2:13][NH:9][CH2:10]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1参加物
4
実験手順
Hydrogen chloride (4N) in ethyl acetate (6 ml) was added to a solution of 1-tertbutoxycarbonyl-3-phenyl-pyrrolidine (1.84 g, 7.4 mmol) in ethyl acetate (2 ml) and the mixture was stirred for 2 hours. After azeotropical removal of the solvent and hydrogen chloride, the residue was partitioned between aqueous potassium carbonate and diethyl ether, and the organic layer was washed with brine, and dried over sodium sulfate. Removal of the solvent afforded 3-phenyl-pyrrolidine (0.95 g, 87%).
後処理
- customAfter azeotropical removal of the solvent and hydrogen chloride
- customthe residue was partitioned between aqueous potassium carbonate and diethyl ether
- washthe organic layer was washed with brine
- dry with materialdried over sodium sulfate
- customRemoval of the solvent
出典と根拠
- ORDレコード
- ord-488288d0781a4f578c13ada92f70da69
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569294B2
反応ノート
読み込み中…