Ethyl orthoformate → 5-Bromo-8-methoxy-[1,2,4]triazolo[4,3-A]pyrazine

HRID 1045720ノート

反応式

HRID 1045720 の反応式
[Br:1][C:2]1[N:3]=[C:4]([NH:10][NH2:11])[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH:12](OCC)(OCC)OCC>>[Br:1][C:2]1[N:3]2[CH:12]=[N:11][N:10]=[C:4]2[C:5]([O:8][CH3:9])=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 31214Ethyl orthoformateHCID 584470301-(6-Bromo-3-methoxypyrazin-2-YL)hydrazine

生成物 1

HCID 584469805-Bromo-8-methoxy-[1,2,4]triazolo[4,3-A]pyrazine

反応条件

温度
130 °C

実験手順

A 100 mL round bottom flask was charged with 5-bromo-3-hydrazinyl-2-methoxypyrazine (0.5 g crude, ˜1.9 mmol) and triethyl orthoformate (5 mL). The resulting mixture was heated at 130° C. overnight. TLC indicated a complete conversion. Work-up: the reaction mixture was concentrated. The residue was purified by flash column chromatography on silica gel with a 1:50 methanol/dichloromethane, to afford 0.28 g (66% for 2 steps) of the product as a pale yellow solid. 1H NMR (300 MHz, CDCl3) δ: 8.93 (s, 1H), 7.47 (s, 1H), 4.18 (s, 3H). MS m/z: 229 (M+H+).

後処理

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was purified by flash column chromatography on silica gel with a 1:50 methanol/dichloromethane

出典と根拠

ORDレコード
ord-362e442d1b174f2c8bb5a32d84c7f6e0
出典データセット
uspto-grants-2013_10
特許番号
US08569300B2

反応ノート

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