Dimethylformamide dimethyl acetal → HCID 58447035、化合物

HRID 1045772ノート

反応式

HRID 1045772 の反応式
[NH2:1][C:2]1[C:7]([Br:8])=[CH:6][N:5]=[C:4]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[N:3]=1.CO[CH:24](OC)[N:25]([CH3:27])[CH3:26]>C1(C)C=CC=CC=1>[Br:8][C:7]1[C:2]([N:1]=[CH:24][N:25]([CH3:27])[CH3:26])=[N:3][C:4]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:13][CH2:14]2)=[N:5][CH:6]=1

参加物

4

反応物 2

HCID 78373Dimethylformamide dimethyl acetalHCID 58446994HCID 58446994、化合物

生成物 1

HCID 58447035HCID 58447035、化合物

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A 100 mL round bottom flask was charged with tert-butyl 4-(4-amino-5-bromopyrimidin-2-yl)piperazine-1-carboxylate (2.0 g, 5.6 mmol), N,N-dimethylformamide dimethyl acetal (0.9 g, 7.3 mmol) and toluene (60 mL). The resulting mixture was heated at reflux for 12 h. Work-up: the solvent was evaporated to dryness to afford the product, which was used in the next step without further purification.

後処理

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 12 h
  3. customthe solvent was evaporated to dryness
  4. customto afford the product, which
  5. customwas used in the next step without further purification

出典と根拠

ORDレコード
ord-33572f8187cf4917a0b1be68b2747ef4
出典データセット
uspto-grants-2013_10
特許番号
US08569300B2

反応ノート

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