Hydrochloric Acid → HCID 58447058、化合物
反応式
[Br:1][C:2]1[C:3]([NH:9][NH2:10])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.Cl.[N:12]([O-])=O.[Na+]>O>[Br:1][C:2]1[C:3]2[N:4]([N:12]=[N:10][N:9]=2)[C:5]([Cl:8])=[N:6][CH:7]=1参加物
5
反応条件
- 温度
- 10 °C
実験手順
A 250 mL round bottom flask was charged with 5-bromo-2-chloro-4-hydrazinylpyrimidine (17 g, crude, 59.2 mmol) and 3 M HCl (600 mL). To the above was added dropwise a solution of NaNO2 (8 g, 0.1 mol) in water (15 mL) at 10° C. The resulting mixture was stirred at 10° C. for 1 h. Work-up: the resulting crystalline solid was collected by filtration. The solid was washed with ethanol (20 mL), and dried to afford 10 g (72%) of the product as a red solid.
後処理
- filtrationthe resulting crystalline solid was collected by filtration
- washThe solid was washed with ethanol (20 mL)
- customdried
出典と根拠
- ORDレコード
- ord-fc4509393b9145a49d03fc8ba30a5fca
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569300B2
反応ノート
読み込み中…