Ethyl orthoformate → 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one
反応式
[NH2:1][C:2]1[C:3]([C:9]([NH2:11])=[O:10])=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.[CH2:12](OC(OCC)OCC)C>>[Cl:8][C:5]1[CH:6]=[CH:7][C:2]2[N:1]=[CH:12][NH:11][C:9](=[O:10])[C:3]=2[N:4]=1参加物
3
反応条件
- 温度
- 145 °C
実験手順
3-amino-6-chloro-pyridine-2-carboxylic acid amide (7.45 g, 43.41 mmol) is taken up in triethylorthoformate (150 mL) and stirred for 3 h at 145° C. After cooling the precipitate formed is filtered off, washed with Et2O, dried and 6-chloro-3H-pyrido[3,2-d]pyrimidin-4-one (HPLC-MS: tRet=0 min; MS (M+H)+=182) is obtained.
後処理
- temperatureAfter cooling the precipitate
- customformed
- filtrationis filtered off
- washwashed with Et2O
- customdried
出典と根拠
- ORDレコード
- ord-81a5e221ad984bde9318edb7564dd633
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569316B2
反応ノート
読み込み中…