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4,6-Dichloro-3-methylpyridazine → (S)-3-((S)-1-(4-(6-chloro-3-methylpyridazin-4-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloro-3-methylpyridazine | HCID 58717049 | — |
| 反応物 | (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one | HCID 59532385 | — |
| 生成物 | (S)-3-((S)-1-(4-(6-chloro-3-methylpyridazin-4-yl)phenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one | HCID 58485379 | — |
反応手順
The isomeric title compounds were prepared by reaction of (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborol-an-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one and 4,6-dichloro-3-methylpyridazine following a procedure analogous to that described in Example 14.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08569292B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-540e269aafcf4c0e8ef8cc61adab6c21 |
| 出典メモ | uspto-grants-2013_10 |