Methanesulfonyl chloride → N-(2-((S)-2-Oxo-6-phenyl-3-((S)-1-(4-(pyridin-3-YL)phenyl)ethyl)-1,3-oxazinan-6-YL)ethyl)methanesulfonamide
反応式
[NH2:1][CH2:2][CH2:3][C@@:4]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5]1.[CH3:31][S:32](Cl)(=[O:34])=[O:33]>>[O:10]=[C:8]1[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[N:21][CH:22]=[CH:23][CH:24]=3)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5][C@:4]([CH2:3][CH2:2][NH:1][S:32]([CH3:31])(=[O:34])=[O:33])([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[O:9]1参加物
3
実験手順
The title compound was prepared from (R)-6-(2-aminoethyl)-6-phenyl-3-((S)-1-(4-(pyridin-3-yl)phenyl)ethyl)-1,3-oxazinan-2-one by treatment with MeSO2Cl. LC-MS Method 2 tR=1.525 min, m/z=480.2; 1H NMR (CDCl3) 1.52 (d, 3H), 2.05-2.32 (m, 6H), 2.81 (s, 3H), 2.86 (m, 1H), 2.93-3.04 (m, 1H), 3.06-3.20 (m, 1H), 4.73 (s, 1H), 5.63 (q, 1H), 6.95 (d, 2H), 7.05-7.22 (m, 2H), 7.23-7.40 (m, 6H), 7.71 (d, 1H), 8.50 (d, 1H), 8.66 (s, 1H).
出典と根拠
- ORDレコード
- ord-50ddef010f1e4036b46515bbbcaeda78
- 出典データセット
- uspto-grants-2013_10