Methyl 4-(bromomethyl)-2-methoxybenzoate → methyl 2-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate

HRID 1046278ノート

反応式

HRID 1046278 の反応式
[C@H:1]12[CH2:7][C@H:4]([NH:5][CH2:6]1)[CH2:3][N:2]2[C:8](OC(C)(C)C)=O.[CH3:15][O:16][C:17]1[CH:26]=[C:25](CBr)[CH:24]=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]>>[CH3:15][O:16][C:17]1[CH:26]=[C:25]([CH2:8][N:2]2[CH2:3][C@@H:4]3[CH2:7][C@H:1]2[CH2:6][NH:5]3)[CH:24]=[CH:23][C:18]=1[C:19]([O:21][CH3:22])=[O:20]

参加物

3

反応物 2

HCID 11288398Methyl 4-(bromomethyl)-2-methoxybenzoateHCID 11521263(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

生成物 1

HCID 68488390methyl 2-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate

実験手順

In like manner, 1,1-dimethylethyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate and methyl 2-methoxy-4-(bromomethyl)benzoate are reacted together to give methyl 2-methoxy-4-[[(1S,4S)-2,5-diazabicyclo[2.2.1]hept-2-yl]methyl]benzoate.

出典と根拠

ORDレコード
ord-ae6b4d55965b4d9ba17add8d9282c7f9
出典データセット
uspto-grants-2013_10
特許番号
US08569303B2

反応ノート

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