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Bicarbonate Ion → (2-Amino-4-hydroxy-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bicarbonate Ion | HCID 769 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium ethanethiolate | HCID 4459711 | — |
| 反応物 | (2-Amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 59259172 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | (2-Amino-4-hydroxy-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 59259050 | — |
反応手順
A mixture of 1.34 g (4.48 mmol) (2-amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone, 1.88 g sodium ethanethiolate and 10 ml DMF are heated for 5 h to 110° C. Saturated aqueous bicarbonate solution (10 ml) and 100 ml water are added. The product is extracted with CH2Cl2 and chromatographed on silica (hexane/ethyl acetate).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08569317B2 |
| 出典データセット | uspto-grants-2013_10 |
| ORD ID | ord-a3af2a98908d4032913ad8256a402946 |
| 出典メモ | uspto-grants-2013_10 |