Oxan-4-yl methanesulfonate → HCID 56942223、化合物
反応式
[CH3:1][O:2][C:3]1[C:8]2[C:9]([C:31]3[CH:32]=[N:33][NH:34][CH:35]=3)=[N:10][N:11](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[C:7]=2[CH:6]=[CH:5][N:4]=1.CS(O[CH:41]1[CH2:46][CH2:45][O:44][CH2:43][CH2:42]1)(=O)=O>>[O:44]1[CH2:45][CH2:46][CH:41]([N:34]2[CH:35]=[C:31]([C:9]3[C:8]4[C:3]([O:2][CH:1]5[CH2:46][CH2:45][O:44][CH2:43][CH2:42]5)=[N:4][CH:5]=[CH:6][C:7]=4[NH:11][N:10]=3)[CH:32]=[N:33]2)[CH2:42][CH2:43]1参加物
3
実験手順
Prepared according to the general procedure described in example 92, by reacting 4-methoxy-3-(1H-pyrazol-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridine with tetrahydro-2H-pyran-4-yl methanesulfonate to give the title compound (26.5 mg, 41% over two steps). LC-MS (Method G): m/z=300.1 [M+H]+; 3.09 min. 1H-NMR (400 MHz, DMSO): δ 13.26 (s, 1H), 8.31 (s, 1H), 8.03 (s, 1H), 7.85 (d, J=5.3, 1H), 7.08 (d, J=5.6, 1H), 4.51 (s, 1H), 4.06 (s, 3H), 4.04-3.93 (m, 2H), 3.58-3.44 (m, 2H), 2.13-1.92 (m, 4H).
後処理
- customPrepared
出典と根拠
- ORDレコード