Water → (R)-benzyl 1-cyanoethylcarbamate
反応式
[CH2:1]([O:8][C:9](=[O:16])[NH:10][C@H:11]([CH3:15])[C:12]([NH2:14])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.ClC1N=C(Cl)N=C(Cl)N=1.O>CN(C)C=O>[CH2:1]([O:8][C:9](=[O:16])[NH:10][C@@H:11]([C:12]#[N:14])[CH3:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
5
実験手順
To a solution of benzyl[(1R)-2-amino-1-methyl-2-oxoethyl]carbamate (10 g, 45 mmol) in 50 mL of N,N-dimethylformamide was added 2,4,6-trichloro-1,3,5-triazine (4.15 g, 22.5 mmol). After 2 h, 100 mL of water was added and the mixture was filtered. The solids were washed with 100 mL aqueous sodium bicarbonate (2×) and dried under vacuum to give pure benzyl[(1R)-1-cyanoethyl]carbamate (7.2 g). MS 205.2 ((M+1).
後処理
- filtrationthe mixture was filtered
- washThe solids were washed with 100 mL aqueous sodium bicarbonate (2×)
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-8d3068298d414843bd0c7c9c8df96137
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569512B2
反応ノート
読み込み中…