Ethanol → HCID 25161047、化合物

HRID 1047855ノート

反応式

HRID 1047855 の反応式
C([O:3][C:4]([C:6]1([NH:15][C:16](=[O:26])[C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]#[N:24])[C:18]=2[CH3:25])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])C.[OH-].[K+].CCO>O>[C:23]([C:19]1[C:18]([CH3:25])=[C:17]([CH:22]=[CH:21][CH:20]=1)[C:16]([NH:15][C:6]1([C:4]([OH:5])=[O:3])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:26])#[N:24]

参加物

5

反応物 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 59314291HCID 59314291、化合物

生成物 1

HCID 25161047HCID 25161047、化合物収率 95%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
50 °C

実験手順

The mixture of 2-(3-cyano-2-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (3) (310 mg, 0.89 mmol), KOH (50% aqueous solution, 2 g, 17.8 mmol), EtOH (10 mL) and water (1 mL) are stirred in a 20 mL vial at 50° C. for 30 min. After concentration in vacuo, the residue is dissolved in water (5 mL) and acidified with conc. HCl until no more white precipitate came out of the water. The filtration affords 2-(3-cyano-2-methyl-benzoylamino)-indan-2-carboxylic acid (238) as white solid (270 mg, 95%).

後処理

  1. concentrationAfter concentration in vacuo
  2. dissolutionthe residue is dissolved in water (5 mL)
  3. filtrationThe filtration

出典と根拠

ORDレコード
ord-7e9508a68ee94dfe9341de8d24d8de57
出典データセット
uspto-grants-2013_10
特許番号
US08569535B2

反応ノート

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