Ethanol → HCID 59314286、化合物

反応式

C([O:3][C:4]([C:6]1([NH:15][C:16](=[O:28])[C:17]2[CH:22]=[CH:21][C:20]([O:23][CH:24]([F:26])[F:25])=[CH:19][C:18]=2[CH3:27])[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1)=[O:5])C.[OH-].[K+].CCO>O>[F:25][CH:24]([F:26])[O:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]([NH:15][C:6]2([C:4]([OH:5])=[O:3])[CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[CH2:7]2)=[O:28])=[C:18]([CH3:27])[CH:19]=1

参加物

反応条件

温度: 50 °C

実験手順

The mixture of 2-(4-difluoromethoxy-2-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (243) (301 mg, 0.77 mmol), KOH (50% aqueous solution, 1.73 g, 15.5 mmol), EtOH (10 mL) and water (1 mL) are stirred in a 20 mL vial at 50° C. for 30 min. After concentration in vacuo, the residue is dissolved in water (10 mL) and acidified with conc. HCl until no more white precipitate came out of the water. The filtration affords 2-(4-difluoromethoxy-2-methyl-benzoylamino)-indan-2-carboxylic acid (244) as white solid (245 mg, 88%).