Hydrochloric Acid → 1-(3-Chlorophenyl)pyrrolidin-3-amine dihydrochloride
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[ClH:21].O1CCOCC1>ClCCl>[ClH:1].[ClH:21].[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1参加物
5
実験手順
tert-Butyl 1-(3-chlorophenyl)pyrrolidin-3-ylcarbamate (120 mg, 0.404 mmol) in dichloromethane (0.5 ml) was treated with 4 molar hydrogen chloride in dioxane (1011 μL, 4.04 mmol) at ambient temperature in an open flask with rapid stirring. After 4 hours, the reaction was concentrated in vacuo to provide the di-hydrochloride salt of the title compound as a crude solid (122 mg, >100%).
後処理
- concentrationthe reaction was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-dcf6c86d683a45c4a4f4e58d82e59c77
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08569522B2
反応ノート
読み込み中…