Bromine → 5-Bromo-2-methoxynicotinonitrile

HRID 1048744

反応式

HRID 1048744 の反応式
C([O-])(=O)C.[Na+].[Br:6]Br.[CH3:8][O:9][C:10]1[N:17]=[CH:16][CH:15]=[CH:14][C:11]=1[C:12]#[N:13]>C(O)(=O)C>[Br:6][C:15]1[CH:16]=[N:17][C:10]([O:9][CH3:8])=[C:11]([CH:14]=1)[C:12]#[N:13]

参加物

5

反応物 3

HCID 24408BromineHCID 2520992-Methoxypyridine-3-carbonitrileHCID 517045Sodium Acetate

生成物 1

HCID 263699225-Bromo-2-methoxynicotinonitrile収率 73%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
70 °C

実験手順

12.23 g (149 mmol) of sodium acetate and then 7.66 ml (149 mmol) of bromine at 0° C. are added to 10 g (74.6 mmol) of a solution of 2-methoxy-nicotinonitrile in 29 ml of acetic acid. The reaction mixture is heated at 70° C. overnight. After returning to room temperature, the reaction medium is added to an ice bath and the precipitate obtained is filtered, rinsed with water and then dried at 50° C. to yield 11.6 g (73%) of 5-bromo-2-methoxy-nicotinonitrile in the form of a white solid.

後処理

  1. customAfter returning to room temperature
  2. additionthe reaction medium is added to an ice bath
  3. customthe precipitate obtained
  4. filtrationis filtered
  5. washrinsed with water
  6. customdried at 50° C.

出典と根拠

ORDレコード
ord-1f45519256d44257bb2a730ed232eafd
出典データセット
uspto-grants-2016_07
特許番号
US09381195B2

関連ノート

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