Water → 5-Hydroxypyridine-3-carbonitrile
反応式
C[O:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9].Cl.N1C=CC=CC=1.O.C(=O)(O)[O-].[Na+]>C(OCC)C>[OH:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9]参加物
6
反応条件
- 温度
- 200 °C
実験手順
A mixture of 1 g of 5-methoxynicotinonitrile (7.46 mmol) and 8.62 g of pyridine hydrochloride is heated at 200° C. for 2 hours. The crude reaction product is diluted in a water fraction several times with diethyl ether. The aqueous phase is basified by adding sodium bicarbonate and then extracted again with diethyl ether. The organic phase is dried and then concentrated to yield 850 mg of 5-hydroxynicotinonitrile (95%) in the form of a beige solid.
後処理
- customThe crude reaction product
- extractionextracted again with diethyl ether
- customThe organic phase is dried
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-ec81dfba4db14ae28f27aa67adb83800
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09381195B2
反応ノート
読み込み中…