Hydrochloric Acid → (R)-4-(1-aminoethyl)benzoic acid hydrochloride

反応式

C([S@@]([NH:7][C@@H:8]([C:10]1[CH:22]=[CH:21][C:13]([C:14]([O:16]C(C)(C)C)=[O:15])=[CH:12][CH:11]=1)[CH3:9])=O)(C)(C)C.[ClH:23]>>[ClH:23].[NH2:7][C@@H:8]([C:10]1[CH:22]=[CH:21][C:13]([C:14]([OH:16])=[O:15])=[CH:12][CH:11]=1)[CH3:9]

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 58417313tert-butyl 4-[(1R)-1-{[(S)-tert-butylsulfinyl]amino}ethyl]benzoate

生成物 1

HCID 67395329(R)-4-(1-aminoethyl)benzoic acid hydrochloride

反応条件

温度: 60 °C

実験手順

To a vial containing tert-butyl 4-[(1R)-1-{[(S)-tert-butylsulfinyl]amino}ethyl]benzoate (0.065 g, 0.20 mmol) was added hydrochloric acid (2.0 mL, 8.0 mmol, 4.0 M in 1,4-dioxane). This vial was capped and heated at 60° C. for 2 h, and then completely evaporated to afford (R)-4-(1-aminoethyl)benzoic acid hydrochloride as a white solid. LC-MS: (FA) ES+ 166.

後処理

customThis vial was capped
customcompletely evaporated

出典と根拠

ORDレコード: ord-b8955f6fe449447f89a4dc485a20e7ad
出典データセット: uspto-grants-2016_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09382197B2

反応ノート

読み込み中…

参加物