関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 4-Fluoro-2-methylbenzaldehyde | HCID 2783217 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 5-Amino-3-(3-chloro-phenylamino)-4-cyano-pyrazole | HCID 10681167 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-((3-chlorophenyl)amino)-5-((4-fluoro-2-methylbenzyl)amino)-1H-pyrazole-4-carbonitrile | HCID 178427852 | — |
反応手順
Dissolved 5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carbonitrile (58 mg) in 4 mL ethanol and added 0.250 mmol of 4-fluoro-2-methylbenzaldehyde followed by a single drop of piperidine. This solution was then heated to 85° C. for 17 hrs, then the ethanol was evaporated and the resulting product was scraped from the reaction vessels. The powder was then resuspended in 4 mL of MeOH and 3 eq. of sodium borohydride was added and left stirring overnight at room temperature. Then MeOH was then evaporated and the product C29 was scraped and collected. (50 mg)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09382237B2 |
|---|
| 出典データセット | uspto-grants-2016_07 |
|---|
| ORD ID | ord-eec21f83b19b4e6e8d5c284ec20ce972 |
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| 出典メモ | uspto-grants-2016_07 |
|---|
