Hydrochloride methanol → HCID 11293051、化合物

HRID 10492ノート

反応式

HRID 10492 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]([S:22]([C:25]1[CH:34]=[CH:33][CH:32]=[C:31]2[C:26]=1[CH:27]=[CH:28][N:29]=[CH:30]2)(=[O:24])=[O:23])[CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=O)(C)(C)C.[ClH:35].CO>>[ClH:35].[CH:30]1[C:31]2[C:26](=[C:25]([S:22]([N:12]([CH2:13][CH2:14][CH2:15][C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[CH2:11][CH2:10][CH2:9][NH2:8])(=[O:23])=[O:24])[CH:34]=[CH:33][CH:32]=2)[CH:27]=[CH:28][N:29]=1

参加物

3

反応物 2

HCID 21893726Hydrochloride methanolHCID 21979966N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-N'-(3-phenylpropyl)-1,3-propylenediamine

生成物 1

HCID 11293051HCID 11293051、化合物

実験手順

Intermediate 2 (913 mg) was added with 10% hydrogen chloride/methanol solution (18 ml, Tokyo Kasei Kogyo) at room temperature and stirred for 25 minutes under reflux by heating. After the reaction, the solvent was evaporated under reduced pressure, and the residue was crystallized from a mixed solvent of methanol and diethyl ether to obtain the title compound (653 mg).

後処理

  1. temperatureunder reflux
  2. temperatureby heating
  3. customAfter the reaction
  4. customthe solvent was evaporated under reduced pressure
  5. customthe residue was crystallized from a mixed solvent of methanol and diethyl ether

出典と根拠

ORDレコード
ord-62100151a08f44888e9b9f008aa8d719
出典データセット
uspto-grants-2006_08
特許番号
US07094789B2

反応ノート

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