Potassium Hydroxide → 2-Ethoxy-2-methylpropanoic acid

HRID 1049301ノート

反応式

HRID 1049301 の反応式
[CH2:1]([O:3][C:4]([CH3:10])([CH3:9])[C:5]([O:7]C)=[O:6])[CH3:2].[OH-].[K+]>CO.O>[CH2:1]([O:3][C:4]([CH3:10])([CH3:9])[C:5]([OH:7])=[O:6])[CH3:2]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 22395030HCID 22395030、化合物

生成物 1

HCID 144596782-Ethoxy-2-methylpropanoic acid収率 76%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒2 回

実験手順

A solution of methyl 2-ethoxy-2-methylpropanoate (1.6 g, 10.95 mmol) in MeOH (14 mL) was treated drop-wise with a solution of KOH (1.228 g, 21.89 mmol) in water (7 mL) and stirred at RT overnight. The mixture was treated with water, washed with Et2O (2×) and the aqueous layer was acidified to pH 2 with 2M HCl. The mixture was extracted with EtOAc (4×) and the combined organics were dried over MgSO4 and concentrated to dryness to afford 2-ethoxy-2-methylpropanoic acid (1.1 g, 76%) as a colorless oil. 1H NMR (400 MHz, DMSO-d6): δ 12.42 (s, 1H), 3.34 (q, J=7.0 Hz, 2H), 1.28 (s, 6H), 1.06 (t, J=7.0 Hz, 3H).

後処理

  1. washwashed with Et2O (2×)
  2. extractionThe mixture was extracted with EtOAc (4×)
  3. dry with materialthe combined organics were dried over MgSO4
  4. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-a837f50bf44f4e8290e7f70652c286fe
出典データセット
uspto-grants-2016_07
特許番号
US09382228B2

反応ノート

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