関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| 反応物 | 4-Methyl-3-cyanopyridine | HCID 227806 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-((1E)-2-(Dimethylamino)ethenyl)-3-pyridinecarbonitrile | HCID 12460447 | — |
反応手順
940 ml of DMF dimethyl acetal are added to a solution of 200 g of 4-methylnicotinonitrile in 940 g of DMF, and the mixture is heated under reflux at 120-110 for 3 days. The mixture is cooled to 35° C., poured into 10 liters of ice-water and cooled at 4° C. for 16 h. The precipitate is filtered off, washed with water and dried, giving 263 g of 4-((E)-2-dimethylaminovinyl)nicotinonitrile; M˜173.22 g/mol; M+H found 174, NMR corresponds.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09382244B2 |
|---|
| 出典データセット | uspto-grants-2016_07 |
|---|
| ORD ID | ord-9c93a404358743598e18c0b4a190c824 |
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| 出典メモ | uspto-grants-2016_07 |
|---|
