Hydrochloride methanol → HCID 21979812、化合物

HRID 10494ノート

反応式

HRID 10494 の反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]([S:23]([C:26]1[CH:35]=[CH:34][CH:33]=[C:32]2[C:27]=1[CH:28]=[CH:29][N:30]=[CH:31]2)(=[O:25])=[O:24])[CH2:13][CH2:14][CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=O)(C)(C)C.[ClH:36].CO>>[ClH:36].[CH:31]1[C:32]2[C:27](=[C:26]([S:23]([N:12]([CH2:13][CH2:14][CH2:15][CH2:16][C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH2:11][CH2:10][CH2:9][NH2:8])(=[O:24])=[O:25])[CH:35]=[CH:34][CH:33]=2)[CH:28]=[CH:29][N:30]=1

参加物

3

反応物 2

HCID 21893726Hydrochloride methanolHCID 21979838N-(tert-butoxycarbonyl)-N'-[(5-isoquinolyl)sulfonyl]-N'-(4-phenylbutyl)-1,3-propylenediamine

生成物 1

HCID 21979812HCID 21979812、化合物

実験手順

According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 6 (249 mg) and 10% hydrogen chloride/methanol solution (5 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (188 mg) as white powdery solid.

後処理

  1. custom(50° C., 2 hours)
  2. customthe solvent was evaporated under reduced pressure
  3. additionThe residue was added with methanol (1 ml) and diethyl ether (3 ml)
  4. customThe deposited precipitates
  5. filtrationwere collected by filtration
  6. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-40e9753b7e624fac9a959e0125d91815
出典データセット
uspto-grants-2006_08
特許番号
US07094789B2

反応ノート

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