反応式
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][O:9][CH2:10][O:11][CH3:12])[CH:3]=1.C(N(CC)CC)C.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.[C:42]([O:46][CH2:47][CH3:48])(=[O:45])[CH:43]=[CH2:44]>CN(C=O)C.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[CH3:12][O:11][CH2:10][O:9][CH2:8][C:4]1[CH:3]=[C:2](/[CH:44]=[CH:43]/[C:42]([O:46][CH2:47][CH3:48])=[O:45])[CH:7]=[CH:6][CH:5]=1参加物
7
実験手順
Under a nitrogen atmosphere, a crude product of 1-bromo-3-((methoxymethoxy)methyl)benzene (3.60 g), triethylamine (6.50 mL), palladium acetate (175 mg), tri-o-tolylphosphine (711 mg) and ethyl acrylate (8.4 mL) were stirred in DMF (30 mL) at 110° C. for 1 hr. The solvent of the reaction mixture was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give the title compound (3.41 g) as a pale-yellow oil.
後処理
- customThe solvent of the reaction mixture was evaporated under reduced pressure
- customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
出典と根拠
- ORDレコード
- ord-cea30461553949a49694e8212e9a80e1
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09382188B2
関連ノート
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