(2,6-Dichlorophenyl)methanesulfonyl chloride → 1-(2,6-Dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepin-5-yl)phenyl]methanesulfonamide

HRID 1049818

反応式

HRID 1049818 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[CH2:18][CH2:19][CH2:20][CH2:21][C:22]=4[CH:23]=[CH:24][C:9]2=3)=[CH:4][CH:3]=1.[Cl:25][C:26]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[C:27]=1[CH2:28][S:29](Cl)(=[O:31])=[O:30]>>[Cl:25][C:26]1[CH:36]=[CH:35][CH:34]=[C:33]([Cl:37])[C:27]=1[CH2:28][S:29]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:14](=[O:15])[CH2:13][C:12](=[O:16])[NH:11][C:10]3[C:17]4[CH2:18][CH2:19][CH2:20][CH2:21][C:22]=4[CH:23]=[CH:24][C:9]2=3)=[CH:6][CH:7]=1)(=[O:31])=[O:30]

参加物

3

反応物 2

HCID 594465(2,6-Dichlorophenyl)methanesulfonyl chlorideHCID 866893185-(4-Aminophenyl)-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione

生成物 1

HCID 1176991571-(2,6-Dichlorophenyl)-N-[4-(2,4-dioxo-1,2,3,4,8,9,10,11-octahydronaphtho[1,2-b][1,4]diazepin-5-yl)phenyl]methanesulfonamide収率 29.4%

実験手順

By using 5-(4-aminophenyl)-1,5,8,9,10,11-hexahydronaphtho[1,2-b][1,4]diazepine-2,4-dione (50 mg, 0.156 mmol) obtained in Example 55, and 2,6-dichlorobenzylsulfonyl chloride (81 mg, 0.312 mmol), the title compound (25 mg, yield 29%) was obtained in the same manner as that of Example 145.

出典と根拠

ORDレコード
ord-149da75f84174553a8eca16efdfaaeb4
出典データセット
uspto-grants-2016_07
特許番号
US09382236B2

関連ノート

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