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Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate → Ethyl 4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate | HCID 21262606 | — |
| 反応物 | 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one | HCID 90014948 | — |
| 生成物 | Ethyl 4-[(5-methoxy-2-oxo-2,3-dihydro-1,3-benzothiazol-6-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate | HCID 73442308 | — |
反応手順
75 mg (332 μmol) ethyl 4-chloro-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (CAS-No: 187725-00-4) were transformed in analogy to example 1 using 6-amino-5-methoxy-1,3-benzothiazol-2(3H)-one to give after working up and purification 20.0 mg (15%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09382255B2 |
| 出典データセット | uspto-grants-2016_07 |
| ORD ID | ord-63520f616092494cb8a169fe16399d56 |
| 出典メモ | uspto-grants-2016_07 |