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HRID 1049919作成日：2026年10月27日
1-Pyrrolidinesulfonyl chloride → tert-Butyl 6-(3-fluoro-5-(pyrrolidine-1-sulfonamido)phenyl)pyrido[3,2-d]pyrimidin-4-ylcarbamate
https://huagongshe.com/reaction/1049919
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Pyrrolidinesulfonyl chloride | HCID 6483902 | — |
| 反応物 | Tert-butyl 6-(3-amino-5-fluorophenyl)pyrido[3,2-d]pyrimidin-4-ylcarbamate | HCID 90032608 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | tert-Butyl 6-(3-fluoro-5-(pyrrolidine-1-sulfonamido)phenyl)pyrido[3,2-d]pyrimidin-4-ylcarbamate | HCID 90054687 | 61% |
反応手順
Pyrrolidine-1-sulfonyl chloride (CAS 1689-02-7) (56 mg, 0.92 mmol) was added to a solution of tert-butyl 6-(3-amino-5-fluorophenyl)pyrido[3,2-d]pyrimidin-4-ylcarbamate (33-A) (300 mg, 0.84 mmol) in pyridine at ice bath. After the reaction mixture was stirred at 60° C. for 4 h, it was partitioned between water and EtOAc and purified by prep-TLC (PE:EtOAc=2:1) to give title product (250 mg, 61%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09382241B2 |
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| 出典データセット | uspto-grants-2016_07 |
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| ORD ID | ord-2304f16ca18648a791a3763cbd5ea650 |
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| 出典メモ | uspto-grants-2016_07 |
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