Hydrochloride methanol → N-(5-Isoquinolyl)-1,4-butylenediamine hydrochloride
反応式
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:15]=1[CH:16]=[CH:17][N:18]=[CH:19]2)=O)(C)(C)C.[ClH:24].CO>>[ClH:24].[CH:19]1[C:20]2[C:15](=[C:14]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][NH2:8])[CH:23]=[CH:22][CH:21]=2)[CH:16]=[CH:17][N:18]=1参加物
3
実験手順
According to the method of Example 1, Step C, deprotection was performed (50° C., 2 hours) by using Intermediate 30 (316 mg) and 10% hydrogen chloride/methanol solution (5 ml). The reaction mixture was cooled to room temperature, and then the solvent was evaporated under reduced pressure. The residue was added with methanol (1 ml) and diethyl ether (3 ml). The deposited precipitates were collected by filtration and washed with diethyl ether to obtain the title compound (276 mg) as light yellow powdery solid.
後処理
- custom(50° C., 2 hours)
- customthe solvent was evaporated under reduced pressure
- additionThe residue was added with methanol (1 ml) and diethyl ether (3 ml)