Hydrochloric Acid → 1383372-63-1

HRID 1051158ノート

反応式

HRID 1051158 の反応式
[CH2:1]([C:8]1([OH:19])[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:20]>>[ClH:20].[CH2:1]([C:8]1([OH:19])[CH2:11][NH:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 659192071383372-62-0

生成物 1

HCID 679741631383372-63-1収率 90%

実験手順

tert-butyl 3-benzyl-3-hydroxyazetidine-1-carboxylate 3 (2.0 gm, 7.59 mmol) was taken into a round bottomed flask and was added methanolic-HCl (25 mL, 20%) and was stirred for 3 h at room temperature. After completion of the reaction (monitored by TLC), the solvent was removed under vacuum to get a white solid as a crude product. The crude product was washed with ethyl acetate repeatedly and then dried well to obtain compound 4 as a white solid (1.36 gm, 90%) which was used without further purification.

後処理

  1. customAfter completion of the reaction (monitored by TLC)
  2. customthe solvent was removed under vacuum
  3. customto get a white solid as a crude product
  4. washThe crude product was washed with ethyl acetate repeatedly
  5. customdried well

出典と根拠

ORDレコード
ord-5a7746f4d6ce42e688f165eb150eb2d9
出典データセット
uspto-grants-2016_07
特許番号
US09388164B2

反応ノート

読み込み中…