Ethanol → 3-Amino-3-(3-fluoro-4-(trifluoromethyl)phenyl)propanoic acid
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])[CH:5]=O.[C:14]([OH:20])(=[O:19])[CH2:15]C(O)=O.C([O-])(=O)C.[NH4+:25].CCO>CCOCC>[NH2:25][CH:5]([C:4]1[CH:7]=[CH:8][C:9]([C:10]([F:13])([F:12])[F:11])=[C:2]([F:1])[CH:3]=1)[CH2:15][C:14]([OH:20])=[O:19]参加物
6
実験手順
A solution of 3-fluoro-4-(trifluoromethyl)benzaldehyde (4.8 g, 25 mmol), malonic acid (2.6 g, 25 mmol), ammonium acetate (0.85 g, 50 mmol) and EtOH (30 mL) was heated at 80° C. for 18 h. The reaction was cooled, diluted with Et2O (50 mL) and filtered to afford 2.0 g (16%) of 3-amino-3-(3-fluoro-4-(trifluoromethyl)phenyl)propanoic acid (93) as a white solid which was used without further purification.
後処理
- temperatureThe reaction was cooled
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-f6ad64d704e5490f92d6335e7e4825e3
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09388171B2
反応ノート
読み込み中…