Diethylamine → N-(4-bromo-1,3-thiazol-5-yl)acetamide
反応式
Br[C:2]1[S:3][C:4]([NH:8][C:9](=[O:11])[CH3:10])=[C:5]([Br:7])[N:6]=1.C(NCC)C>C(O)C.[Ni]>[Br:7][C:5]1[N:6]=[CH:2][S:3][C:4]=1[NH:8][C:9](=[O:11])[CH3:10]参加物
5
実験手順
A mixture of N-(2,4-dibromothiazol-5-yl)acetamide from example 1.4 (0.35 g, 1.17 mmol), diethylamine (0.085 g, 1.17 mmol) and Raney Ni (0.14 g, 2.33 mmol) in ethanol (50 mL) was stirred at room temperature for 12 h in a 100 mL round-bottomed flask to give a black solution. The reaction mixture was filtered and concentrated to give the title compound (0.20 g, 0.91 mmol, 78%) as a yellow solid which was directly used for the next step without purification.
後処理
- customto give a black solution
- filtrationThe reaction mixture was filtered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-20f70f9f594f4f83b1277f2452573fc9
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09388180B2
反応ノート
読み込み中…