Acetic Anhydride → N-(2-Methylthiazol-5-yl)acetamide

HRID 1051425ノート

反応式

HRID 1051425 の反応式
CCN(CC)CC.Cl.[CH3:9][C:10]1[S:11][C:12]([NH2:15])=[CH:13][N:14]=1.[CH3:16][C:17](OC(C)=O)=[O:18]>C(Cl)Cl>[CH3:9][C:10]1[S:11][C:12]([NH:15][C:17](=[O:18])[CH3:16])=[CH:13][N:14]=1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 867155582-Methylthiazol-5-amine hydrochloride

生成物 1

HCID 73554716N-(2-Methylthiazol-5-yl)acetamide収率 77.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of Et3N (1.4 ml, 10 mmol) and 2-methylthiazol-5-amine hydrochloride (1 g, 6.6 mmol) in DCM (30 mL) was added Ac2O (0.94 mL, 10 mmol). The mixture was stirred at room temperature for 3 h. The reaction solution was concentrated, deposited onto silica gel and loaded onto a silica gel column and eluted with EA to give the title compound (0.8 g, yield: 77%).

後処理

  1. concentrationThe reaction solution was concentrated
  2. washeluted with EA

出典と根拠

ORDレコード
ord-9260f1e1a35e46948e3fb32945d1b786
出典データセット
uspto-grants-2016_07
特許番号
US09388180B2

反応ノート

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