1,2,3,4-Tetrahydroisoquinoline → HCID 86729264、化合物

HRID 1051484ノート

反応式

HRID 1051484 の反応式
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:9]=[CH:10][CH:11]=1.[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][NH:21]1>CCO>[CH2:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:23][CH2:22][N:21]1[CH2:3][CH:2]([OH:1])[CH2:4][O:5][C:6]1[CH:7]=[C:8]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH:9]=[CH:10][CH:11]=1

参加物

4

反応物 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 86729263HCID 86729263、化合物

生成物 1

HCID 86729264HCID 86729264、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
100 °C

実験手順

To a solution of tert-butyl (3-(oxiran-2-ylmethoxy)phenyl)carbamate 1.5 g, 5.66 mmol) in EtOH (30 mL) was added 1,2,3,4-tetrahydroisoquinoline 0.828 g, 6.23 mmol). The reaction mixture was heated at 100° C. for 4 h. The solvent was then removed by concentration and the residue dissolved in ethyl acetate, washed with water and the separated organic layer dried over sodium sulfate and concentrated to obtain a crude product. This product was used in next step without further purification.

後処理

  1. customThe solvent was then removed by concentration
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washwashed with water
  4. dry with materialthe separated organic layer dried over sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-51fdd328dcbd48eda8ac70703671b3df
出典データセット
uspto-grants-2016_07
特許番号
US09388173B2

反応ノート

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