2-Amino-5-chloropyridine → ethyl N-{[(5-chloro-2-pyridinyl)amino]carbothioyl}carbamate
反応式
[CH2:1]([O:3][C:4]([N:6]=[C:7]=[S:8])=[O:5])[CH3:2].[NH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=1>O1CCOCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:10]([NH:9][C:7]([NH:6][C:4](=[O:5])[O:3][CH2:1][CH3:2])=[S:8])=[N:11][CH:12]=1参加物
4
実験手順
Ethoxycarbonylisothiocyanate (3.37 g) was added to a stirred solution of 2-amino-5-chloropyridine (3.0 g) in dioxane (100 mL). The mixture was stirred at r.t. for 14 h. The solvent was removed in vacuum. The solid was dissolved in dichloromethane and methanol (100:1), filtered and the solvent was removed in vacuum to give a solid that was recrystallized from ethyl acetate to give 4.4 g of the title compound.
後処理
- customThe solvent was removed in vacuum
- dissolutionThe solid was dissolved in dichloromethane
- filtrationmethanol (100:1), filtered
- customthe solvent was removed in vacuum
- customto give a solid
- customthat was recrystallized from ethyl acetate
出典と根拠
- ORDレコード
- ord-480fe829e8f345e6b252b489f35d79cf
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09388177B2
反応ノート
読み込み中…