関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Bromoisoquinoline | HCID 736487 | — |
| 反応物 | 2-(Di-tert-butylphosphino)biphenyl | HCID 2734215 | — |
| 反応物 | Sodium t-butoxide | HCID 23676156 | — |
| 反応物 | HCID 178418966 | HCID 178418966 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | HCID 178418965 | HCID 178418965 | 77.1% |
反応手順
Under nitrogen atmosphere, a suspension of 5-bromoisoquinoline (253 mg), tris(dibenzylideneacetone)palladium(0) (58 mg), 2-(di-tert-butylphosphino)biphenyl (74 mg), Intermediate 38 (311 mg) and sodium tert-butoxide (165 mg) in toluene was stirred with heating at 70° C. for 3 hours. The reaction mixture was cooled to room temperature and purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (320 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07094789B2 |
|---|
| 出典データセット | uspto-grants-2006_08 |
|---|
| ORD ID | ord-62ca8446a3a044da8763ed93973f3667 |
|---|
| 出典メモ | uspto-grants-2006_08 |
|---|
