Lithium hydroxide, monohydrate → 2-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid

HRID 1051916ノート

反応式

HRID 1051916 の反応式
[CH3:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([O:13]C)=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1.O[Li].O>C1COCC1.CO.O>[CH3:1][C:2]1[S:3][C:4]2[CH:10]([C:11]([OH:13])=[O:12])[CH2:9][CH2:8][CH2:7][C:5]=2[N:6]=1

参加物

4

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 90303556Methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate

生成物 1

HCID 822769032-Methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid

試薬・触媒・溶媒 1

HCID 21892291Methanol tetrahydrofuran water溶媒

実験手順

A mixture of methyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (59 mg, 0.28 mmol) and LiOH.H2O (14 mg, 0.33 mmol) in THF/MeOH/H2O (2.5 mL, 3:1:1) was stirred at RT for 2 h. The mixture was acidified to pH=3 and extracted with EtOAc. The comb. org. layers were dried over MgSO4, and conc. in vacuo.

後処理

  1. extractionextracted with EtOAc
  2. dry with materiallayers were dried over MgSO4

出典と根拠

ORDレコード
ord-05c36b194d0f492d9a17c4ac3aa5227e
出典データセット
uspto-grants-2016_07
特許番号
US09388197B2

反応ノート

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