Lithium hydroxide, monohydrate → 2-Phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylic acid
反応式
[C:1]1([C:7]2[S:8][C:9]3[CH:15]([C:16]([O:18]C)=[O:17])[CH2:14][CH2:13][CH2:12][C:10]=3[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[Li].O>C1COCC1.CO.O>[C:1]1([C:7]2[S:8][C:9]3[CH:15]([C:16]([OH:18])=[O:17])[CH2:14][CH2:13][CH2:12][C:10]=3[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
A mixture of methyl 2-phenyl-4,5,6,7-tetrahydrobenzo[d]thiazole-7-carboxylate (12.0 mg, 0.044 mmol) and LiOH.H2O (2.7 mg, 0.065 mmol) in THF/MeOH/H2O (1 mL, 3:1:1) was stirred at RT for 45 min. The mixture was acidified to pH=3 and extracted with DCM. The comb. org. layers were dried over MgSO4, and conc. in vacuo.
後処理
- extractionextracted with DCM
- dry with materiallayers were dried over MgSO4
出典と根拠
- ORDレコード
- ord-ad6a866ce8264dd5b9b1a2f2ab32d3fa
- 出典データセット
- uspto-grants-2016_07
- 特許番号
- US09388197B2
反応ノート
読み込み中…