Hydrochloric Acid → (S)-2-Amino-4,4-dimethylpentan-1-ol hydrochloride

HRID 1052136ノート

反応式

HRID 1052136 の反応式
C(OC(=O)[NH:7][C@H:8]([CH2:14][OH:15])[CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[NH2:7][C@@H:8]([CH2:9][C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:14][OH:15]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 58280489((S)-1-hydroxymethyl-3,3-dimethyl-butyl)-carbamic acid tert-butyl ester

生成物 1

HCID 90020033(S)-2-Amino-4,4-dimethylpentan-1-ol hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of ((S)-1-hydroxymethyl-3,3-dimethyl-butyl)-carbamic acid tert-butyl ester (200 mg, 0.605 mmol) in dioxane (4 mL) was added HCl (4N in dioxane, 6.05 mL, 24.21 mmol). The reaction mixture was stirred at RT overnight and concentrated to give the desired material as a white powder which was used without further purification in the next. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 7.79 (bs, 3H), 5.37 (m, 1H), 3.60 (m, 1H), 3.40 (overlap with water, m, 1H), 3.09 (m, 1H), 1.47 (dd, 1H), 1.33 (dd, 1H), 0.92 (s, 9H).

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-1b8f75b3ea9843b1b6394e40b5659b2f
出典データセット
uspto-grants-2016_07
特許番号
US09388199B2

反応ノート

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