Hydrochloric Acid → (S)-2-(1-Amino-3-(benzylthio)propyl)-3-phenylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one
反応式
[CH2:1]([S:8][CH2:9][CH2:10][C@H:11]([NH:28]C(=O)OC(C)(C)C)[C:12]1[N:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16](=[O:24])[C:15]2=[CH:25][CH:26]=[CH:27][N:14]2[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.O1CCOCC1>>[NH2:28][C@H:11]([C:12]1[N:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:16](=[O:24])[C:15]2=[CH:25][CH:26]=[CH:27][N:14]2[N:13]=1)[CH2:10][CH2:9][S:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
(S)-tert-Butyl (3-(benzylthio)-1-(4-oxo-3-phenyl-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-2-yl)propyl)carbamate (12 mg, 0.02 mmol) was treated with a solution of hydrochloric acid in dioxane (4M, 92 μl, 0.37 mmol) according to the method described in Preparation 1 to obtain 10 mg (96% yield) of the title compound as a yellow solid. Purity 100%.