Triethylamine → HCID 90103295、化合物

反応式

[Br:1][C:2]1[CH:10]=[C:9]([NH2:11])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2.[CH3:12][S:13](Cl)(=[O:15])=[O:14].C(N(CC)CC)C>>[Br:1][C:2]1[CH:10]=[C:9]([NH:11][S:13]([CH3:12])(=[O:15])=[O:14])[CH:8]=[C:7]2[C:3]=1[CH:4]=[N:5][NH:6]2

参加物

反応物 3

HCID 8471Triethylamine

HCID 31297Methanesulfonyl chloride

HCID 247280674-Bromo-1H-indazol-6-amine

生成物 1

HCID 90103295HCID 90103295、化合物収率 61.5%

実験手順

4-Bromo-1H-indazol-6-amine (500 mg, 2.36 mmol) was treated with methanesulfonyl chloride (130 μl, 1.68 mmol) and triethylamine (49 μl, 3.55 mmol) according to the method described in Preparation 15b. The residue was purified using SP1® Purification System to give 300 mg (49% yield) of the title compound. Purity 80%.