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Sodium Cyanide → 2-(3-Cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Cyanide | HCID 8929 | — |
| 反応物 | 3-[5-(5-Methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propanol | HCID 19694374 | — |
| 生成物 | 2-(3-Cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran | HCID 19694364 | 80% |
反応手順
In the same manner as in Example 13, 3-[5-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-benzofuranyl]propanol was mesylated and then reacted with sodium cyanide to yield 2-(3-cyanopropyl)-5-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzofuran (yield 80%), which was then recrystallized from acetone-isopropyl ether to yield colorless prisms having a melting point of 114° to 115° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723479 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-667e2aee4c9a4838b14ae6bea3b0b581 |
| 出典メモ | uspto-grants-1998_03 |