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3-Pentanamine → 4-(1-Ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Pentanamine | HCID 12019 | — |
| 反応物 | 3-Quinolinecarboxylic acid, 4-chloro-8-methoxy-, ethyl ester | HCID 304557 | — |
| 生成物 | 4-(1-Ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester | HCID 67250481 | — |
反応手順
4-Chloro-8-methoxy-quinoline-3-carboxylic acid ethyl ester (250 mg, 0.94 mmol) was treated with 1-ethyl-propylamine following general procedure B to afford 4-(1-ethyl-propylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester (240 mg). Thus obtained amino-ester was hydrolyzed to the corresponding acid in quantitative yield using general procedure D and then transformed into the corresponding ethylamide (160 mg) following general procedure E.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09393245B2 |
| 出典データセット | uspto-grants-2016_07 |
| ORD ID | ord-043a835e708e437e94eeb713bc6ef055 |
| 出典メモ | uspto-grants-2016_07 |