2-Acetyl-3-bromo-benzothiophene → 1-(3-(6-((4-(Dimethylamino)piperidin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)benzo[b]thiophen-2-yl)ethanone

反応式

[Br:39][c:40]1[c:41]2[c:42]([s:43][c:44]1[C:45]([CH3:46])=[O:47])[cH:48][cH:49][cH:50][cH:51]2.[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][c:10]2[cH:11][c:12]3[n:13][c:14]([Sn:25]([CH2:26][CH2:27][CH2:28][CH3:29])([CH2:30][CH2:31][CH2:32][CH3:33])[CH2:34][CH2:35][CH2:36][CH3:37])[n:15][c:16]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[c:17]3[s:18]2)[CH2:7][CH2:8]1)[CH3:38]>>[CH3:1][N:2]([CH:3]1[CH2:4][CH2:5][N:6]([CH2:9][c:10]2[cH:11][c:12]3[n:13][c:14](-[c:40]4[c:41]5[c:42]([s:43][c:44]4[C:45]([CH3:46])=[O:47])[cH:48][cH:49][cH:50][cH:51]5)[n:15][c:16]([N:19]4[CH2:20][CH2:21][O:22][CH2:23][CH2:24]4)[c:17]3[s:18]2)[CH2:7][CH2:8]1)[CH3:38]

参加物

反応物 2

HCID 107061652-Acetyl-3-bromo-benzothiophene

HCID 59605498Dimethyl-[1-(4-morpholin-4-yl-2-(tributylstannanyl)thieno[3,2-d]pyrimidin-6-ylmethyl)piperidin-4-yl]amine

生成物 1

HCID 498322731-(3-(6-((4-(Dimethylamino)piperidin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidin-2-yl)benzo[b]thiophen-2-yl)ethanone

出典と根拠

ORDレコード: ord-696a3f8472624b6faeee7fe70ca4acfa
出典データセット: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

反応ノート

読み込み中…